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Search Results for " CC chemokine receptor "

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カタログ番号	製品名	別名	ターゲット
T11481	GSK2239633A		CCR
			CCR
T4300	AZD2098		CCR
	AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.		CCR
TQ0103	INCB3344		CCR
			CCR
T4674	SB297006	SB 297006	CCR
	SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ...		CCR
TQ0283	RS102895		CCR
	RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.		CCR
T5384	RS 504393		CCR
	RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).		CCR
T24700	R243	R 243,R-243	CCR
	R243 is CCR8 signaling and chemotaxis inhibitor.		CCR
T30258	AZD-4818	CCR1 antagonist	CCR
	AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.		CCR
T7499	TAK-779	Takeda 779	HIV Protease , CXCR , CCR
	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).		HIV Protease , CXCR , CCR
T10425	AZ084		CCR
	AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.		CCR
T16111	ML604086		CCR
	ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 binding to CCR8 on circulating T-cells.		CCR
T16091	MK-0812 Succinate		Others , CCR
	MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2.		Others , CCR
T11699	J-113863		CCR
	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor...		CCR
T3430	PF-4136309	INCB8761,PF 4136309	CCR
	PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.		CCR
T4584	BMS-813160	BMS 813160	CCR
	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.		CCR
T17225	Vercirnon	CCX282-B,GSK-1605786,Traficet-EN	CCR
	Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.		CCR
T12773	RS102895 hydrochloride		Others , 5-HT Receptor , CCR
	RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).		Others , 5-HT Receptor , CCR
T2375	BX471	BX 471,BX-471,ZK-811752	CCR
	BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.		CCR
T10639	C-021 dihydrochloride		CCR
	C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM.		CCR
T6016	Maraviroc	Celsentri,UK-427857,Selzentry	HIV Protease , CCR
	Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.		HIV Protease , CCR
T13114	CCR2 antagonist 4	Teijin compound 1	CCR
			CCR
T7624	DAPTA	DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir	HIV Protease , CCR
	DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.		HIV Protease , CCR
TQ0297	Cenicriviroc	TAK-652,TBR-652	HIV Protease , CCR
	Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity.		HIV Protease , CCR
T21870	C-021	4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-	CCR
	C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s ...		CCR
T14900	CCR2-RA-[R]		CCR
	CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).		CCR
T2386	Pirfenidone	S-7701,AMR-69,S-7701,AMR69	CCR , TGF-beta/Smad
	Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum...		CCR , TGF-beta/Smad
T3435	Vicriviroc maleate	SCH-D (maleate),SCH-417690 (maleate)	HIV Protease , CCR
	Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment...		HIV Protease , CCR
T76782	Mogamulizumab	KW-0761	CXCR
	Mogamulizumab (KW-0761) is a monoclonal antibody against T cell CC chemokine receptor 4. Mogamulizumab has anticancer activity, eliminating tumor cells through antibody dependent cytotoxicity (ADCC), and can be used to s...		CXCR
T29181	YM-355179	YM 355179
	YM-355179 is a novel, selective antagonist of CC chemokine receptor 3 with oral activity.
T68984	AF-399/42018025
	AF-399/42018025 is a CC chemokine receptor 4 (CCR4) antagonist.
T69830	GSK2239633
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2...
T10713	CCR4 antagonist 2		Calcium Channel
	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the n...		Calcium Channel
T26642	Aplaviroc hydrochloride	AK602,AK 602,GW873140A,GW-873140,GW873140,AK-602,Aplaviroc HCl
	Aplaviroc is a human cellular CC chemokine receptor 5 (CCR5) entry inhibitor. Aplaviroc binds specifically to CCR5 and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In...
T10716	CCR7 Ligand 1	CCR7-Cmp2105	Others
			Others
T69081	KRH-1636
	KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell ...
T69523	BMS-681
	BMS-681 is an orthosteric antagonist of chemokine receptor 2 (CCR2) that forms a ternary complex with CCR2 and its allosteric antagonist, CCR2-RA-[R]. Together, the complex inhibits chemokine binding with BVMS-681 in the...

Compounds

Synonym: CCR1 antagonist

Target: HIV Protease, CXCR, CCR

Synonym: INCB8761,PF 4136309

Synonym: CCX282-B,GSK-1605786,Traficet-EN

Target: CCR

RS102895 hydrochloride

T12773

Synonym:

Target: Others, 5-HT Receptor, CCR

BX471

T2375

Synonym: BX 471,BX-471,ZK-811752

Target: CCR

C-021 dihydrochloride

Synonym: Celsentri,UK-427857,Selzentry

Target: HIV Protease, CCR

CCR2 antagonist 4

T13114

Synonym: Teijin compound 1

Target: CCR

DAPTA

T7624

Synonym: DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir

Target: HIV Protease, CCR

Cenicriviroc

TQ0297

Synonym: TAK-652,TBR-652

Target: HIV Protease, CCR

C-021

T21870

Synonym: 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-

Synonym: S-7701,AMR-69,S-7701,AMR69

Target: CCR, TGF-beta/Smad

Vicriviroc maleate

T3435

Synonym: SCH-D (maleate),SCH-417690 (maleate)

Target: HIV Protease, CCR

Target: Calcium Channel

Aplaviroc hydrochloride

T26642

Synonym: AK602,AK 602,GW873140A,GW-873140,GW873140,AK-602,Aplaviroc HCl

Target:

CCR7 Ligand 1

T10716

Synonym: CCR7-Cmp2105

カタログ番号	製品名	別名	ターゲット
T6413	Bindarit	AF2838	CCR
	Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.		CCR
TN1273	7,4'-Dihydroxyflavone	4',7-Dihydroxyflavone	NF-κB , COX , HDAC , CCR , NOD
	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2.		NF-κB , COX , HDAC , CCR , NOD

天然物製品

7,4'-Dihydroxyflavone

TN1273

Synonym: 4',7-Dihydroxyflavone

Target: NF-κB, COX, HDAC, CCR, NOD

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01065	CCR4 Protein-VLP, Human, Recombinant (His)	Human	HEK293 Cells
	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-01064	CCR4 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-01066	CCR6 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684.
TMPY-03779	CCL27 Protein, Human, Recombinant (His)	Human	E. coli
	CCL27, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27 is chemotactic for skin-associated memory T lymphoc...
TMPJ-01001	CCL11 Protein, Human, Recombinant	Human	E. coli
	C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of all...
TMPK-00896	CCR8 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPK-01316	CCR8 Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293 Cells
	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPJ-01409	CCL27 Protein, Human, Recombinant	Human	E. coli
	Human Chemokine (C-C Motif) Ligand 27 (CCL27) is a small cytokine that is a member of the CC chemokine family; it is expressed in numerous tissues, including gonads, thymus, placenta and skin. CCL27 elicits its chemotact...
TMPJ-00018	CCL16 Protein, Human, Recombinant	Human	E. coli
	CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC c...
TMPY-02795	Eotaxin-2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in imm...
TMPK-00897	CCR8 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPJ-00873	CCL3L1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	C-C Motif Chemokine 3-Like 1 (CCL3L1) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL3L1 is a ligand for CCR1, CCR3 and CCR5. CCL3L1 binds to several chemokine receptors including che...
TMPJ-01000	CCL9 Protein, Mouse, Recombinant	Mouse	E. coli
	C-C motif chemokine 9(CCL9) is an 11 kDa, secreted, monomeric polypeptide that belongs to the beta (or CC) intercrine family of chemokines. It is expressed mainly in the liver, lung, and the thymus, although some express...
TMPJ-00009	CCL2 Protein, Human, Recombinant	Human	E. coli
	The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for mono...
TMPJ-00831	CCL3 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta. CCL3 expression can be induced in a variety of hematopoietic cells, fibroblasts, ...
TMPY-05353	CCL26 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3),...

CCR4 Protein-VLP, Human, Recombinant (His)

TMPH-01065

Species: Human

Expression System: HEK293 Cells

CCR4 Protein, Human, Recombinant (His & SUMO)

TMPH-01064

Species: Human

Expression System: E. coli

CCR6 Protein, Human, Recombinant (His & Myc)

TMPH-01066

Species: Human

Expression System: E. coli

CCL27 Protein, Human, Recombinant (His)

TMPY-03779

Species: Human

Expression System: E. coli

CCL11 Protein, Human, Recombinant

TMPJ-01001

Species: Human

Expression System: E. coli

CCR8 Protein, Human, Recombinant (hFc)

TMPK-00896

Species: Human

Expression System: HEK293 Cells

CCR8 Protein, Cynomolgus, Recombinant (mFc)

TMPK-01316

Species: Cynomolgus

Expression System: HEK293 Cells

CCL27 Protein, Human, Recombinant

TMPJ-01409

Species: Human

Expression System: E. coli

CCL16 Protein, Human, Recombinant

TMPJ-00018

Species: Human

Expression System: E. coli

Eotaxin-2 Protein, Human, Recombinant (His)

TMPY-02795

Species: Human

Expression System: Baculovirus Insect Cells

CCR8 Protein, Human, Recombinant (mFc)

TMPK-00897

Species: Human

Expression System: HEK293 Cells

CCL3L1 Protein, Human, Recombinant (His)

TMPJ-00873

Species: Human

Expression System: HEK293 Cells

CCL9 Protein, Mouse, Recombinant

TMPJ-01000

Species: Mouse

Expression System: E. coli

CCL2 Protein, Human, Recombinant

TMPJ-00009

Species: Human

Expression System: E. coli

CCL3 Protein, Mouse, Recombinant (His)

TMPJ-00831

Species: Mouse

Expression System: E. coli

CCL26 Protein, Human, Recombinant

TMPY-05353

Species: Human

Expression System: Baculovirus Insect Cells

カタログ番号	製品名
L7600	Chemokine Inhibitor Library		59 compounds
	A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening;

ライブラリー

Chemokine Inhibitor Library

L7600

Compounds: 59